Microbiology
Dr. Vipin Mohan Dan
Position: Scientist
Mobile No: 9496696021
Email: vipindan@gmail.com
Qualification: Ph.D. Micobial Technology (Amity University, 2011), Post doc- Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram (2013-2016).
Specialization: Anticancer agents, Antimicrobial agents, Anti-biofilm agents , mTOR inhibitors, Breast and Cervical Cancer research
Personal Biography
Expertise in the area of anticancer drugs from microbial source, mTOR inhibitors, Breast and Cervical cancer research, and antimicrobial and anti-biofilm agents. Research led to identification of two novel mTOR inhibitors, Urdamycin E &V, the compounds which were found to be superior in activity compared to clinically used mTOR inhibitor, Rapamycin. Identified novel anti-biofilm agents from microbial sources which are efficient against human pathogens. Also contributed to identifying factors responsible for breast cancer stemness and uncovered novel diagnostic marker and therapeutic target for breast cancer assessment and treatment, respectively
Projects & Selected Publications
Projects
- Survey, Inventory, Bioprospecting and Sustainable Utilization of Microbial and Lichen Diversity of Western Ghats- KSCSTE-plan project.
- Anticancer and antioxidant potential of Streptomyces MP10- KSCSTE-Plan project- (Completed).
- Bio-prospecting of rare Actinomycetes diversity of Kerala Western Ghats forest soil for novel anticancer compounds- a High throughput analysis (SERB- DBT)- (Completed).
Publications
- Sahayasheela V.J., Lankadasari M.B., Dan V.M., Dastager S.G., Pandian G.N., Sugiyama H. (2022). Artificial intelligence in microbial natural product drug discovery: current and emerging role. Nat. Prod. Rep., 39, 2215-2230 https://doi.org/10.1039/D2NP00035K
- Dan V.M., Raveendran R.S., Baby S. Resistance to Intervention: Paclitaxel in Breast Cancer. Mini Rev Med Chem. 2021;21(10):1237-1268. https://doi.org/10.2174/1389557520999201214234421
- Dan V.M., J. S. V, C. J. S, Sanawar R., Lekshmi A., Kumar R.A., Santhosh Kumar T.R., Marelli U.K., Dastager S.G., Pillai M.R. (2020). Molecular Networking and Whole-Genome Analysis Aid Discovery of an Angucycline That Inactivates mTORC1/C2 and Induces Programmed Cell Death. ACS Chem Biol. 20;15(3):780-788. https://doi.org/10.1021/acschembio.0c00026
- Dan V.M., Varghese T.S., Viswanathan G., Baby S. (2020). Ellipticine, its Derivatives: Re-evaluation of Clinical Suitability with the Aid of Drug Delivery Systems. Curr Cancer Drug Targets. 20(1):33-46. https://doi.org/10.2174/1568009619666190927150131
- Sanawar R., Dan V.M., Santhoshkumar T.R., Kumar R., Pillai M.R. (2019) Estrogen receptor-α regulation of microRNA-590 targets FAM171A1: a modifier of breast cancer invasiveness. Oncogenesis. 8(1):5 https://doi.org/10.1038/s41389-018-0113-z
Project Fellows
Work: Identification and exploration of anti-biofilm agents from streptomyces diversity of Western Ghats.
Work: Studies on the antimicrobial potential of wild Mushrooms of Western Ghats